1-Hydroxybenzotriazole
CAS 2592-95-2
EC 219-989-7
Formula C6H5N3O
MW 135.12 g/mol
Heterocyclic Compounds Pharmaceuticals & HealthcareBiotechnology & Life Sciences Catalysis
Description
1-Hydroxybenzotriazole (CAS 2592-95-2), commonly known as HBT or 1-HOBt and also referred to as Benzazimidol or 1-Benzotriazolol, is a bicyclic organic compound registered under EC 219-989-7 with the molecular formula C6H5N3O. It carries no assigned E-code and is classified as a pharmaceutical intermediate.
HBT functions primarily as a coupling additive in peptide synthesis, where it suppresses racemisation and activates carboxyl groups to form reactive esters that drive amide bond formation. It also serves as a catalyst in acylation reactions and is used in the preparation of active pharmaceutical ingredients requiring controlled stereochemical integrity.
This compound is supplied as a pharmaceutical-grade solid and falls under REACH regulation within the European market. It is classified under HS code 29339900 for customs purposes. Procurement teams should confirm grade specifications and documentation requirements, including safety data sheets, prior to ordering.
HBT functions primarily as a coupling additive in peptide synthesis, where it suppresses racemisation and activates carboxyl groups to form reactive esters that drive amide bond formation. It also serves as a catalyst in acylation reactions and is used in the preparation of active pharmaceutical ingredients requiring controlled stereochemical integrity.
This compound is supplied as a pharmaceutical-grade solid and falls under REACH regulation within the European market. It is classified under HS code 29339900 for customs purposes. Procurement teams should confirm grade specifications and documentation requirements, including safety data sheets, prior to ordering.
Physical Properties
| Melting Point | 136.00 °C |
| Boiling Point | 149-150 °C |
| Density | 1 g/cm 3 |
| Flash Point | 95 °C |
| Appearance | white to light yellow powder |
| Color | White to off-white crystalline powder |
| Form | Solid |
| Water Solubility | 4.201g/L at 29℃ |
| Vapor Pressure | 0.009Pa at 25℃ |
| Refractive Index | n20/D 1.488 |
| Log P | 0.146 at 25℃ |
Safety & Handling (Learn More)
Danger GHS01 GHS07
H
H203H319H412
P
P210P230P240P250P273P280P372P373P401P501P264+P265P337+P317P370+P380P305+P351+P338
Trade & Regulatory
| HS Code | 29339900 |
Other Names
HydroxybenzotriazoleN-HydroxybenzotriazoleHBTHOBt1-HOBBenzazimidol1-Benzotriazolol
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Raw Materials
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