2,2-dimethylbutanoyl chloride
CAS 5856-77-9
EC 227-478-5
Formula C6H11ClO
MW 134.6 g/mol
Pharmaceutical Intermediates Biotechnology & Life SciencesPersonal Care & CosmeticsPharmaceuticals & Healthcare Preservation & BiocideCatalysisFlavoring & Acidulant
Description
2,2-Dimethylbutanoyl chloride (CAS 5856-77-9, EC 227-478-5) is an acyl chloride supplied as a liquid under the synonyms 2,2-Dimethylbutyryl chloride and Dimethylbutyrylchloride. It carries no assigned E-code. It belongs to the acid chloride class of reactive acylating agents within the pharmaceutical intermediates category.
In pharmaceutical synthesis, it functions as an acylating agent, transferring its acyl group to amines or alcohols to build protected intermediates or active pharmaceutical ingredients. In personal care formulations, its antimicrobial activity derives from disruption of microbial cell membranes, supporting preservation systems. It also serves as a catalyst component and fragrance precursor in select specialty applications.
This material is supplied under REACH compliance and is available in standard laboratory and bulk packaging formats suited to industrial procurement. Buyers should confirm grade specifications and purity certificates directly with the supplier. It is classified under HS code 29159000 for customs and import documentation purposes.
In pharmaceutical synthesis, it functions as an acylating agent, transferring its acyl group to amines or alcohols to build protected intermediates or active pharmaceutical ingredients. In personal care formulations, its antimicrobial activity derives from disruption of microbial cell membranes, supporting preservation systems. It also serves as a catalyst component and fragrance precursor in select specialty applications.
This material is supplied under REACH compliance and is available in standard laboratory and bulk packaging formats suited to industrial procurement. Buyers should confirm grade specifications and purity certificates directly with the supplier. It is classified under HS code 29159000 for customs and import documentation purposes.
Physical Properties
| Melting Point | -20 °C |
| Boiling Point | 130.3-131.3 °C |
| Density | 0.9787 g/cm³ @ Temp: 20 °C |
| Flash Point | 29°C |
| Color | Clear Colorless |
| Form | Oil |
| Water Solubility | Reacts with water. Soluble in chloroform and ethyl acetate. |
| Refractive Index | 1.4240 |
Safety & Handling (Learn More)
Danger GHS02 GHS05
H
H226H290H314H318
P
P210P233P234P240P241P242P243P260P264P280P316P317P321P363P390P405P406P501P264+P265P304+P340P370+P378P403+P235P301+P330+P331P302+P361+P354P303+P361+P353P305+P354+P338
Trade & Regulatory
| HS Code | 29159000 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
Dimethylbutyrylchloride2,2-dimethylbutyl chloride2,2-Dimethylbutyryl chloride2,2-DimethylbutyricacidchlorideButyryl Chloride, 2,2-Dimethyl-Butanoyl chloride, 2,2-dimethyl-2,2-Dimethylbutyric acid chloride
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