2-Chloro-5-methoxyaniline
CAS 2401-24-3
EC 219-277-6
Formula C7H8ClNO
MW 157.6 g/mol
Pharmaceutical Intermediates Pharmaceuticals & Healthcare Polymerization Initiation
Description
2-Chloro-5-methoxyaniline (CAS 2401-24-3, EC 219-277-6) is an aromatic amine supplied under common trade names including 2-Chloro-m-anisidine, 6-Chloro-m-anisidine, and 3-Amino-4-chloroanisole. With molecular formula C7H8ClNO, it belongs to the chlorinated anisidine family and carries HS code 2922290090 for customs classification.
In pharmaceutical synthesis, 2-Chloro-5-methoxyaniline serves as a key building block where its free amine group undergoes condensation and coupling reactions to construct heterocyclic drug intermediates. It also functions as a polymerization initiator, where the amine group generates reactive species that control chain initiation in specialty polymer systems.
This material is available for procurement under REACH compliance and is subject to standard EU chemical regulations. It is supplied in solid form ranging from powder to lump, with liquid grades also available depending on batch conditions. Packaging formats are confirmed at the time of order based on volume requirements.
In pharmaceutical synthesis, 2-Chloro-5-methoxyaniline serves as a key building block where its free amine group undergoes condensation and coupling reactions to construct heterocyclic drug intermediates. It also functions as a polymerization initiator, where the amine group generates reactive species that control chain initiation in specialty polymer systems.
This material is available for procurement under REACH compliance and is subject to standard EU chemical regulations. It is supplied in solid form ranging from powder to lump, with liquid grades also available depending on batch conditions. Packaging formats are confirmed at the time of order based on volume requirements.
Physical Properties
| Melting Point | 27 °C |
| Boiling Point | 136-137 °C @ Press: 10 Torr |
| Density | 1.261 g/mL at 25 °C |
| Flash Point | 135-137°C/12mm |
| Color | White or Colorless to Yellow to Orange |
| Form | powder to lump to clear liquid |
| Water Solubility | Slightly soluble in water. |
| Refractive Index | 1.5848 |
Safety & Handling (Learn More)
Danger GHS06 GHS07 GHS08
H
H301H302H311H312H315H319H335H373
P
P260P261P262P264P270P271P280P316P317P319P321P330P405P501P264+P265P301+P316P301+P317P302+P352P304+P340P332+P317P337+P317P361+P364P362+P364P403+P233P305+P351+P338
Trade & Regulatory
| HS Code | 2922290090 |
| Storage Class | 13 - Non Combustible Solids |
| WGK (Germany) | 3 |
Other Names
6-Chloro-m-anisidine2-CHLORO-M-ANISIDINE2-Chloro-5-anisidinem-Anisidine, 6-chloro-3-AMINO-4-CHLOROANISOLE6-Chloro-m-anisidine (NH2=1)
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