2-Methyltetrahydrofuran

2-Methyltetrahydrofuran, commonly abbreviated as MTHF or 2-Methyloxolane, is a cyclic ether solvent derived from furfural. It is also known under the names Tetrahydrosilvan and 2-Methylfuranidine. No E-code is assigned; it is identified under CAS 96-47-9 and EC 202-507-4.

In pharmaceutical synthesis, MTHF serves as a direct replacement for THF and dichloromethane in Grignard reactions and metal-catalysed couplings, offering a higher boiling point and easier aqueous phase separation. In food and personal care formulations, it functions as a carrier solvent for flavourants and fragrance compounds, improving dispersion and controlled release in the final product.

MTHF is supplied in technical and high-purity grades compliant with REACH registration requirements. Procurement teams should confirm suitability against FCC or Ph.Eur. monographs depending on the target application. Standard packaging includes drums and IBC containers, with documentation available for EU regulatory submissions under HS code 29321900.