3β-Cholesteryl chloride

3-Cholesteryl chloride (CAS 910-31-6, EC 213-004-4, formula C27H45Cl) is a halogenated cholesterol derivative also referenced as Cholesteryl Chloride and NSC 2084. It carries no assigned E-code. It is classified as a pharmaceutical intermediate within the steroid chemistry family.

In pharmaceutical synthesis, 3-Cholesteryl chloride serves as a reactive building block for constructing cholesterol-conjugated drug molecules, where the C-3 chloro group undergoes nucleophilic substitution to attach targeting ligands or active pharmaceutical ingredients. It is also used in lipid chemistry research to prepare functionalized sterol derivatives for membrane studies and liposomal formulation development.

This material is supplied as a pharmaceutical-grade intermediate compliant with REACH registration requirements applicable to EU commerce. It is available in standard laboratory and bulk quantities, typically packaged under inert atmosphere to maintain stability. Procurement teams should confirm certificate of analysis specifications, including purity and residual solvent profiles, prior to ordering.