4-Bromophenyl isocyanate
CAS 2493-02-9
EC 219-662-9
Formula C7H4BrNO
MW 198.02 g/mol
Pharmaceutical Intermediates Pharmaceuticals & HealthcareBiotechnology & Life SciencesPlastics & Polymers Polymerization Initiation
Description
4-Bromophenyl isocyanate (CAS 2493-02-9, EC 219-662-9) is an aromatic isocyanate compound also referenced as p-Bromophenyl isocyanate, p-Bromocarbanil, and NSC 8037. It carries no assigned E-code and is classified under HS code 29291090 within the broader category of organic isocyanates.
In pharmaceutical synthesis, the reactive isocyanate group reacts selectively with amines and alcohols to form urea and carbamate linkages, making it a key building block for active pharmaceutical ingredient scaffolds. In polymer chemistry, it functions as a polymerization initiator, introducing brominated aryl segments into polyurethane chains to modify thermal and mechanical properties.
This material is supplied as a white to light beige crystalline solid and is subject to REACH registration requirements for EU procurement. Buyers should confirm purity grade specifications and request a current safety data sheet prior to ordering, as handling requirements apply to isocyanate-class compounds.
In pharmaceutical synthesis, the reactive isocyanate group reacts selectively with amines and alcohols to form urea and carbamate linkages, making it a key building block for active pharmaceutical ingredient scaffolds. In polymer chemistry, it functions as a polymerization initiator, introducing brominated aryl segments into polyurethane chains to modify thermal and mechanical properties.
This material is supplied as a white to light beige crystalline solid and is subject to REACH registration requirements for EU procurement. Buyers should confirm purity grade specifications and request a current safety data sheet prior to ordering, as handling requirements apply to isocyanate-class compounds.
Physical Properties
| Melting Point | 134 °C |
| Boiling Point | 78-80 °C @ Press: 5 Torr |
| Density | 1.6077 (rough estimate) |
| Flash Point | 229 °F |
| Appearance | WHITE TO LIGHT BEIGE CRYSTALLINE SOLID |
| Color | White to light beige |
| Form | Crystalline Solid |
| Water Solubility | Sparingly soluble in water (0.40 g/L at 25°C). |
| Refractive Index | 1.5500 (estimate) |
Safety & Handling (Learn More)
Danger GHS07 GHS08
H
H312H315H319H332H334H335
P
P233P260P261P264P271P280P284P317P319P321P403P405P501P264+P265P302+P352P304+P340P332+P317P337+P317P342+P316P362+P364P403+P233P305+P351+P338
Trade & Regulatory
| HS Code | 29291090 |
| WGK (Germany) | 3 |
Other Names
1-bromo-4-isocyanatobenzenep-Bromophenyl Isocyanatep-Bromocarbanilp-Bromophenylcarbonimide1-bromo-4-isocyanato-benzen
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