4-Chloro-m-cresol
CAS 59-50-7
EC 200-431-6
Formula C7H7ClO
MW 142.58 g/mol
Pharmaceutical Intermediates Personal Care & CosmeticsPharmaceuticals & HealthcareCoatings, Adhesives, Sealants & Elastomers Preservation & BiocideAntioxidant & StabilizerFlame RetardancyUV Protection & Stabilization
Description
4-Chloro-m-cresol (CAS 59-50-7), also known as 4-CMC or chlorocresol and sold under trade names including Parol and Raschit, is a chlorinated phenolic compound classified as a pharmaceutical intermediate. It carries no assigned E-code for food applications.
In pharmaceutical and personal care manufacturing, 4-CMC functions as an antimicrobial preservative by disrupting bacterial cell membranes, making it effective in injectable formulations, topical creams, and hair dye systems. In coatings and adhesive formulations, it acts as an antioxidant and UV stabilizer, inhibiting oxidative degradation of polymer matrices.
4-Chloro-m-cresol is supplied as a crystalline solid meeting Ph.Eur. monograph standards, with technical and pharmaceutical grades available to suit different application requirements. The substance is registered under REACH and classified under HS code 29081000. Standard packaging includes fiber drums and polyethylene-lined containers.
In pharmaceutical and personal care manufacturing, 4-CMC functions as an antimicrobial preservative by disrupting bacterial cell membranes, making it effective in injectable formulations, topical creams, and hair dye systems. In coatings and adhesive formulations, it acts as an antioxidant and UV stabilizer, inhibiting oxidative degradation of polymer matrices.
4-Chloro-m-cresol is supplied as a crystalline solid meeting Ph.Eur. monograph standards, with technical and pharmaceutical grades available to suit different application requirements. The substance is registered under REACH and classified under HS code 29081000. Standard packaging includes fiber drums and polyethylene-lined containers.
Physical Properties
| Melting Point | 67 °C |
| Boiling Point | 235 °C |
| Density | 1.37 g/cm³ |
| Flash Point | 118 °C |
| Appearance | White (pure) or pink crystalline solid. Crystals turn pink on exposure to air and light. Phenolic odor. |
| Color | White |
| Form | Tablets |
| Water Solubility | 4 g/L (20 ºC) |
| Vapor Pressure | <0.1 hPa (20 °C) |
| Refractive Index | 1.5449 (estimate) |
| pH | 6.5 (1g/l, H2O, 20℃) |
| Log P | 3.100 |
Safety & Handling (Learn More)
Danger GHS05 GHS07 GHS09 GHS08
H
H302H312H314H317H318H335H373H400H412
P
P260P261P264P270P271P272P273P280P316P317P319P321P330P363P391P405P501P264+P265P301+P317P302+P352P304+P340P333+P317P362+P364P403+P233P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 29081000 |
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| WGK (Germany) | 2 |
Other Names
P-Chlorocresol4-chloro-3-methylphenolchlorocresolPCMCParol4-CMCRaschitRaschit K
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