5β-Tetrahydrocortisol
CAS 53-02-1
EC 200-159-8
Formula C21H34O5
MW 366.49 g/mol
Pharmaceutical Intermediates Pharmaceuticals & Healthcare
Description
5β-Tetrahydrocortisol (CAS 53-02-1, EC 200-159-8) is a naturally occurring metabolite of cortisol, produced in the liver through reduction of the cortisone pathway. It is also referenced under the designations Ba 2682, ba2682, and the abbreviation tetrahydrof, and carries no assigned E-code.
In pharmaceutical development, 5β-Tetrahydrocortisol serves primarily as a reference standard and synthetic intermediate in corticosteroid research, where its defined stereochemistry at the 5β position is used to characterise metabolic pathways and validate analytical assay methods. It also functions as a building block in the synthesis of structurally related steroidal compounds, enabling controlled modification of the cortisol backbone.
This material is supplied as a solid and is subject to REACH registration requirements applicable within the European Economic Area. Procurement teams should confirm purity grade specifications and documentation requirements, including certificate of analysis and safety data sheet, prior to ordering. Packaging formats are confirmed at the point of enquiry.
In pharmaceutical development, 5β-Tetrahydrocortisol serves primarily as a reference standard and synthetic intermediate in corticosteroid research, where its defined stereochemistry at the 5β position is used to characterise metabolic pathways and validate analytical assay methods. It also functions as a building block in the synthesis of structurally related steroidal compounds, enabling controlled modification of the cortisol backbone.
This material is supplied as a solid and is subject to REACH registration requirements applicable within the European Economic Area. Procurement teams should confirm purity grade specifications and documentation requirements, including certificate of analysis and safety data sheet, prior to ordering. Packaging formats are confirmed at the point of enquiry.
Physical Properties
| Melting Point | 202-204 °C |
| Boiling Point | 65-67 °C(lit.) |
| Density | 0.889 g/mL at 25 °C(lit.) |
| Flash Point | 1 °F |
| Color | <10(APHA) |
| Form | Solid |
| Vapor Pressure | 114 mm Hg ( 15 °C) |
| Refractive Index | n 20/D 1.407(lit.) |
Trade & Regulatory
| UN Number | 2056 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 1 |
Other Names
DihydrocortisonTetrahydrocortisolC05472ba2682Ba 2682Allo-3αSOLVENT AtetrahydrofUrocortisol
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