Borane-tetrahydrofuran complex

Borane-tetrahydrofuran complex (Borane-THF, Borane-THF complex, CAS 14044-65-6) is a stabilised boron hydride reagent supplied as a 1:1 molar complex with tetrahydrofuran. The THF coordination moderates the reactivity of free borane, making it practical to handle and dose in synthetic workflows. No E-code applies to this substance.

In pharmaceutical synthesis, Borane-THF serves as a selective reducing agent for carboxylic acids and amides under mild conditions, leaving ester and nitro groups intact. It also initiates ring-opening polymerisation of cyclic monomers in polymer research and functions as a hydroboration reagent, adding across carbon-carbon double bonds to produce organoboron intermediates for further coupling chemistry.

This material is supplied under REACH registration and handled in accordance with applicable EU chemical regulations. Standard commercial formats include stabilised solutions in THF at defined molar concentrations, packaged in inert-atmosphere containers to prevent decomposition. Procurement teams should confirm concentration specification and inhibitor content when sourcing.