d-Yohimbine

D-Yohimbine (CAS 146-48-5, EC 205-672-0) is an indole alkaloid derived from the bark of Pausinystalia yohimbe and related Rauwolfia species. It is also known under the synonyms Corynine, Johimbin, Yohimbin, and Raubasin. No E-code is assigned. Molecular formula: C21H26N2O3.

In pharmaceutical synthesis, D-Yohimbine serves primarily as an intermediate in the production of alpha-2 adrenergic receptor antagonists, where its stereochemical configuration determines receptor binding selectivity. It is also used in pharmacological research as a reference compound to study adrenergic signalling pathways and in the preparation of standardised botanical extracts for clinical formulations.

D-Yohimbine is supplied as a solid alkaloid for pharmaceutical-grade applications and is subject to REACH registration requirements within the European Economic Area. Procurement quantities and packaging formats are available on request. Buyers should confirm applicable national controlled substance classifications prior to ordering.