Diethyl sulfate
CAS 64-67-5
EC 200-589-6
Formula C4H10O4S
MW 154.18 g/mol
Solvents Pharmaceuticals & HealthcareAgriculture & FeedPersonal Care & Cosmetics Preservation & BiocideSolvent & Carrier
Description
Diethyl sulfate (CAS 64-67-5, EC 200-589-6), also known as ethyl sulfate or Diaethylsulfat, is a colourless oily liquid with the molecular formula C4H10O4S. It carries no assigned E-code and is classified under HS code 29209090. It is commercially referenced under NSC 56380.
In pharmaceutical and agrochemical synthesis, diethyl sulfate functions as an ethylating agent, transferring ethyl groups to amines, alcohols, and phenols under controlled conditions to produce active intermediates. In preservation applications, it acts as an antimicrobial agent, disrupting microbial cell membranes, and serves as a solvent carrier in personal care and cosmetic formulations.
Diethyl sulfate is supplied as a technical-grade liquid and is subject to REACH registration requirements within the European Union. Procurement teams should note its classification as a Category 1B carcinogen under CLP, requiring compliant packaging, labelling, and documented exposure controls throughout the supply chain.
In pharmaceutical and agrochemical synthesis, diethyl sulfate functions as an ethylating agent, transferring ethyl groups to amines, alcohols, and phenols under controlled conditions to produce active intermediates. In preservation applications, it acts as an antimicrobial agent, disrupting microbial cell membranes, and serves as a solvent carrier in personal care and cosmetic formulations.
Diethyl sulfate is supplied as a technical-grade liquid and is subject to REACH registration requirements within the European Union. Procurement teams should note its classification as a Category 1B carcinogen under CLP, requiring compliant packaging, labelling, and documented exposure controls throughout the supply chain.
Physical Properties
| Melting Point | -25 °C |
| Boiling Point | 90-91 °C @ Press: 12 Torr |
| Density | 1.172 g/cm³ @ Temp: 25 °C |
| Flash Point | 173 °F |
| Appearance | colourless oily liquid |
| Color | Clear |
| Odor | char. faint ether odor, irritating after-effect |
| Form | Liquid |
| Water Solubility | 5 g/L (20 ºC) |
| Vapor Pressure | <0.01 mm Hg ( 20 °C) |
| Refractive Index | n 20/D 1.399(lit.) |
Safety & Handling (Learn More)
Danger GHS05 GHS07 GHS08 GHS06
H
H302H311H312H314H318H331H332H340H350H371H412
P
P203P260P261P262P264P270P271P273P280P316P317P318P321P330P363P405P501P264+P265P301+P317P302+P352P304+P340P308+P316P361+P364P362+P364P403+P233P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 29209090 |
| UN Number | 1594 |
| ADR Class | 6.1 |
| Packing Group | II |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| WGK (Germany) | 3 |
Other Names
DESEthylsulpateETHYL SULFATEDiaethylsulfatDiethyl sulphate
Related Products
Derivatives
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