Dimethyl sulfate

Dimethyl sulfate (CAS 77-78-1, EC 201-058-1, formula C2H6O4S) is a reactive methylating agent also referenced under the names Methyl sulfate, NSC 56194, and ai3-52118. It carries no E-code designation and is classified as a colourless liquid within the solvents category.

In pharmaceutical synthesis, dimethyl sulfate transfers methyl groups to nitrogen, oxygen, or sulfur nucleophiles, enabling the production of methylated active ingredients and intermediates. In antimicrobial formulations, it acts by alkylating microbial cell components, disrupting cellular function. It also serves as a humectant precursor in select personal care applications.

Dimethyl sulfate is supplied subject to REACH regulation (EC 1907/2006) given its classification as a highly toxic and carcinogenic substance, requiring strict handling controls. Procurement requires confirmed end-use documentation. Buyers should confirm applicable grade specifications and packaging formats directly with the supplier to ensure regulatory compliance.