Dimethylacetamide

Dimethylacetamide (CAS 127-19-5) is a high-boiling polar aprotic solvent also known by the abbreviations DMA and DMAC, and by trade designations including Ejjyxa 2 and CBC 510337. It carries no assigned E-code. Its molecular formula is C4H9NO and it is classified under HS code 29241900.

In pharmaceutical manufacturing, DMAC dissolves poorly soluble active ingredients and facilitates membrane casting for drug-delivery films by maintaining a stable, homogeneous solution phase. In biotechnology, it functions as a reaction medium for peptide synthesis and polymer processing, where its low reactivity toward nucleophiles prevents unwanted side reactions. It also exhibits documented antimicrobial and buffering activity in formulation contexts.

DMAC is supplied in pharmaceutical and technical grades meeting REACH registration requirements for the European market. Standard packaging includes drums and IBC containers, with documentation available to support Ph.Eur.-aligned quality systems. Buyers should note its classification as a substance of very high concern (SVHC) candidate under REACH due to reproductive toxicity.