Duloxetine

Duloxetine (CAS 116539-59-4, EC 601-438-0, formula C18H19NOS) is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) supplied as a pharmaceutical intermediate. Also referenced as LY248686 and LY 248686, it serves as the active pharmaceutical ingredient or synthetic precursor in antidepressant and analgesic drug development programs.

In pharmaceutical manufacturing, duloxetine is used primarily in the synthesis of finished-dose antidepressant formulations targeting major depressive disorder and generalized anxiety disorder. It functions by inhibiting the reuptake transporters for both serotonin and norepinephrine, making it a key building block for CNS-active drug candidates and reference standard preparations.

This material is available in pharmaceutical-grade form, manufactured in compliance with GMP requirements applicable to active pharmaceutical ingredients under ICH Q7 guidelines. Procurement quantities range from research-scale to bulk industrial supply. Buyers should confirm REACH registration status and applicable import/export controls prior to ordering.