Ethanesulfonic acid
CAS 594-45-6
EC 209-843-0
Formula C2H6O3S
MW 110.13 g/mol
Organic Acids Pharmaceuticals & HealthcareBiotechnology & Life Sciences pH Regulation & BufferingSolvent & CarrierCatalysis
Description
Ethanesulfonic acid (CAS 594-45-6, EC 209-843-0), also known as ethylsulfonic acid or ethylsulphonic acid, is a short-chain aliphatic sulfonic acid with the molecular formula C2H6O3S. It carries no assigned E-code and is classified under HS code 29041000 within the organic sulfonic acids group.
In pharmaceutical synthesis, ethanesulfonic acid serves as a catalyst in esterification and condensation reactions, where its strong acidity and water miscibility drive conversion without introducing halide contamination. It also functions as a pH buffer and counterion source in active pharmaceutical ingredient salt formation, improving compound solubility and crystalline stability.
The material is supplied as a liquid and is subject to REACH registration requirements for European commerce. Procurement teams should confirm supplier documentation including SDS, certificate of analysis, and purity specification relevant to pharmaceutical or biotechnology grade applications. Packaging formats and minimum order quantities vary by supplier.
In pharmaceutical synthesis, ethanesulfonic acid serves as a catalyst in esterification and condensation reactions, where its strong acidity and water miscibility drive conversion without introducing halide contamination. It also functions as a pH buffer and counterion source in active pharmaceutical ingredient salt formation, improving compound solubility and crystalline stability.
The material is supplied as a liquid and is subject to REACH registration requirements for European commerce. Procurement teams should confirm supplier documentation including SDS, certificate of analysis, and purity specification relevant to pharmaceutical or biotechnology grade applications. Packaging formats and minimum order quantities vary by supplier.
Physical Properties
| Melting Point | -17 °C |
| Boiling Point | 100 °C @ Press: 0.5 Torr |
| Density | 1.360 g/cm³ @ Temp: 22 °C |
| Flash Point | >230 °F |
| Appearance | clear yellow to brown liquid |
| Color | Colorless to yellow |
| Form | Liquid |
| Water Solubility | soluble |
| Refractive Index | n 20/D 1.434(lit.) |
| Log P | -1.577 (est) |
Safety & Handling (Learn More)
Danger GHS05 GHS07
H
H290H302H312H314H318H335H302+H312
P
P234P260P261P264P270P271P280P316P317P319P321P330P363P390P405P406P501P264+P265P301+P317P302+P352P304+P340P362+P364P403+P233P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 29041000 |
| UN Number | 2586 |
| ADR Class | 8 |
| Packing Group | III |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| WGK (Germany) | 3 |
Other Names
ethylsulfonic acidethylsulphonic acidethanesulfonateETHANSULFONIC ACIDETHANESULPHONIC ACID
Related Products
Need a chemical? Get a quote within 24 hours.