Furosemide
CAS 54-31-9
EC 200-203-6
Formula C12H11ClN2O5S
MW 330.74 g/mol
Pharmaceutical Intermediates Pharmaceuticals & Healthcare Preservation & Biocide
Description
Furosemide (CAS 54-31-9) is a sulfonamide-derived loop diuretic active pharmaceutical ingredient, commercially known under trade names including Lasix and LB 502, and also referenced as frusemide or furosemid. It carries no assigned E-code and is classified within pharmaceutical intermediates under HS code 2935904000.
In pharmaceutical manufacturing, furosemide serves as the active substance in diuretic formulations targeting edema associated with cardiac, hepatic, and renal conditions. It acts by inhibiting the sodium-potassium-chloride cotransporter in the renal loop of Henle, blocking electrolyte reabsorption and promoting fluid excretion. It is also investigated as a functional component in antimicrobial and preservation research contexts.
Furosemide is supplied as a white to light yellow crystalline powder meeting Ph.Eur. and USP compendial standards. It is subject to REACH registration requirements within the European market. Packaging is available in quantities suited to pharmaceutical-grade procurement, with documentation supporting GMP-compliant supply chains.
In pharmaceutical manufacturing, furosemide serves as the active substance in diuretic formulations targeting edema associated with cardiac, hepatic, and renal conditions. It acts by inhibiting the sodium-potassium-chloride cotransporter in the renal loop of Henle, blocking electrolyte reabsorption and promoting fluid excretion. It is also investigated as a functional component in antimicrobial and preservation research contexts.
Furosemide is supplied as a white to light yellow crystalline powder meeting Ph.Eur. and USP compendial standards. It is subject to REACH registration requirements within the European market. Packaging is available in quantities suited to pharmaceutical-grade procurement, with documentation supporting GMP-compliant supply chains.
Physical Properties
| Melting Point | 206 °C |
| Boiling Point | 582.1±60.0 °C(Predicted) |
| Density | 1.594 g/cm³ (solid) |
| Flash Point | 11 °C |
| Appearance | white to light yellow crystal powde |
| Color | White to Off-White |
| Form | powder |
| Water Solubility | Soluble in acetone, DMF or methanol. Slightly soluble in water |
| Refractive Index | 1.6580 (estimate) |
Safety & Handling (Learn More)
Danger GHS07 GHS08
H
H315H319H335H351H360H361
P
P203P261P264P271P280P318P319P321P405P501P264+P265P302+P352P304+P340P332+P317P337+P317P362+P364P403+P233P305+P351+P338
Trade & Regulatory
| HS Code | 2935904000 |
| UN Number | 1230 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| WGK (Germany) | 3 |
Other Names
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acidmethforylthiazidinedihydroflumethiazide4-chloro-N-furfuryl-5-sulfamoylanthranilic acidLasix"mita"LB 502Frusemide
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Raw Materials
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