Glycerol formal
CAS 4740-78-7
EC 225-248-9
Formula C4H8O3
MW 104.105 g/mol
Solvents Pharmaceuticals & HealthcarePersonal Care & CosmeticsAgriculture & FeedLubricants & Metalworking Solvent & Carrier
Description
Glycerol formal (CAS 4740-78-7) is a cyclic acetal solvent derived from glycerol and formaldehyde, available under the names 1,3-Dioxan-5-ol, m-Dioxan-5-ol, and 1,3-Formalglycerol. It carries no assigned E-code and is registered under EC 225-248-9. Its molecular formula is C4H8O3.
In pharmaceutical formulation, glycerol formal functions as a co-solvent that improves the solubility of poorly water-soluble active ingredients in injectable and topical preparations. In agrochemical concentrates, it dissolves crop protection actives while remaining miscible with water upon dilution. Personal care formulators use it as a carrier solvent where low odour and skin compatibility are required.
Glycerol formal is supplied as a clear liquid suitable for pharmaceutical and industrial applications, with grades available to meet relevant purity specifications under REACH compliance. It is classified under HS code 29329900. Packaging formats typically include drums and intermediate bulk containers for B2B supply across Europe.
In pharmaceutical formulation, glycerol formal functions as a co-solvent that improves the solubility of poorly water-soluble active ingredients in injectable and topical preparations. In agrochemical concentrates, it dissolves crop protection actives while remaining miscible with water upon dilution. Personal care formulators use it as a carrier solvent where low odour and skin compatibility are required.
Glycerol formal is supplied as a clear liquid suitable for pharmaceutical and industrial applications, with grades available to meet relevant purity specifications under REACH compliance. It is classified under HS code 29329900. Packaging formats typically include drums and intermediate bulk containers for B2B supply across Europe.
Physical Properties
| Boiling Point | 50 °C @ Press: 55 Torr |
| Density | 1.2200 g/cm³ @ Temp: 20 °C |
| Flash Point | 97°C |
| Appearance | Clear liquid |
| Color | Colorless to Almost colorless |
| Form | clear liquid |
| Refractive Index | n 20/D 1.451(lit.) |
Safety & Handling (Learn More)
Warning GHS07
H
H319
P
P280P264+P265P337+P317P305+P351+P338
Trade & Regulatory
| HS Code | 29329900 |
| WGK (Germany) | 3 |
Other Names
1,3-dioxan-5-ol5-M-Dioxanolm-Dioxan-5-olGlycerol F0rmal1,3-Formalglycerol5-Hydroxy-m-dioxane5-Hydroxy-1,3-dioxane
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