Guanosine 5′-monophosphate

Guanosine 5-monophosphate, commonly known as GMP or 5-GMP and designated E 626 in the EU, is a purine nucleotide functioning as a flavour-enhancing food additive. It is the free acid form of the compound, distinct from its disodium salt, and carries the molecular formula C10H14N5O8P.

In food formulations, GMP acts synergistically with glutamates to amplify umami taste perception, allowing manufacturers to reduce total MSG content while maintaining flavour intensity. In pharmaceutical and biotechnology applications, it serves as a biochemical reference standard and a building block in nucleotide synthesis workflows.

GMP is available in food-grade and reagent-grade forms, with compliance referenced against FCC and JECFA specifications under E 626 classification. It falls under REACH regulation for EU supply chains. Procurement quantities typically range from kilogram to multi-tonne scale depending on application requirements.