Hexafluoroisopropyl methyl ether

Hexafluoroisopropyl methyl ether (CAS 13171-18-1, EC 603-501-8) is a fluorinated ether solvent commercially known under designations including HFE-356mmz1 and Isoindoklon, with the molecular formula C4H4F6O. It carries no assigned E-code and is classified within the hydrofluoroether solvent family.

In pharmaceutical research and formulation development, this compound functions as a specialty solvent for dissolving fluorinated active compounds and intermediates where conventional solvents show poor compatibility. Its fluorinated backbone reduces hydrogen-bonding interactions, enabling selective solvation of highly fluorinated substrates. It has also been investigated as a carrier medium in inhalation-related research contexts.

Hexafluoroisopropyl methyl ether is supplied in liquid form under REACH compliance for the European market. Procurement teams should confirm applicable RoHS and F-gas regulatory considerations given its fluorinated composition. Packaging formats and available grades should be confirmed directly with the supplier based on order volume and application requirements.