Hydrochlorothiazide
CAS 58-93-5
EC 200-403-3
Formula C7H8ClN3O4S2
MW 297.74 g/mol
Pharmaceutical Intermediates Pharmaceuticals & Healthcare Preservation & Biocide
Description
Hydrochlorothiazide (CAS 58-93-5), also known under trade names Diclotride, Dichlotride, and Chlorosulthiadil, and abbreviated as HCT or HCTZ, is a sulfonamide-derived thiazide compound with the molecular formula C7H8ClN3O4S2. It carries no assigned E-code and is classified within pharmaceutical intermediates.
In pharmaceutical manufacturing, hydrochlorothiazide serves primarily as an active pharmaceutical ingredient in antihypertensive formulations, where it acts on renal tubules to inhibit sodium-chloride reabsorption, promoting diuresis. It is also used as a reference standard and synthetic intermediate in the development of combination cardiovascular drug products.
Hydrochlorothiazide is sourced in pharmaceutical-grade form compliant with Ph.Eur. and USP monograph specifications. It falls under HS code 29350090 and is subject to REACH registration requirements within the EU. Packaging is typically supplied in sealed containers suited to controlled-substance handling protocols for regulated pharmaceutical procurement.
In pharmaceutical manufacturing, hydrochlorothiazide serves primarily as an active pharmaceutical ingredient in antihypertensive formulations, where it acts on renal tubules to inhibit sodium-chloride reabsorption, promoting diuresis. It is also used as a reference standard and synthetic intermediate in the development of combination cardiovascular drug products.
Hydrochlorothiazide is sourced in pharmaceutical-grade form compliant with Ph.Eur. and USP monograph specifications. It falls under HS code 29350090 and is subject to REACH registration requirements within the EU. Packaging is typically supplied in sealed containers suited to controlled-substance handling protocols for regulated pharmaceutical procurement.
Physical Properties
| Melting Point | 273-275 °C |
| Boiling Point | 577.0±60.0 °C(Predicted) |
| Density | 1.512 g/cm³ (Liquid) |
| Flash Point | 9°C |
| Appearance | White Solid |
| Color | White to Off-White |
| Odor | wh. or pract. wh. cryst. powd., odorless |
| Form | solid |
| Water Solubility | 722mg/L(25 ºC) |
| Refractive Index | 1.6100 (estimate) |
| Log P | -0.070 |
Safety & Handling (Learn More)
Danger GHS07 GHS08
H
H302H317H334H372
P
P233P260P261P264P270P271P272P280P284P319P321P330P403P501P301+P317P302+P352P304+P340P333+P317P342+P316P362+P364
Trade & Regulatory
| HS Code | 29350090 |
| UN Number | 1230 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 2 |
Other Names
hydrochlorthiazidechlorsulfonamidodihydrobenzothiadiazine dioxideHCTZSu 5879AquariusDiclotrideDichlotrideChlorosulthiadil
Related Products
Raw Materials
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