Hydroxychloroquine
CAS 118-42-3
EC 204-249-8
Formula C18H26ClN3O
MW 335.88 g/mol
Pharmaceutical Intermediates Pharmaceuticals & Healthcare
Description
Hydroxychloroquine (CAS 118-42-3, EC 204-249-8, formula C18H26ClN3O) is a synthetic aminoquinoline compound available under trade names including Plaquenil and Oxychlorochin, with historical designations WIN 1258 and Win 1258-2. It carries no assigned E-code and is classified within pharmaceutical intermediates.
In pharmaceutical manufacturing, hydroxychloroquine serves as an active pharmaceutical ingredient in formulations targeting autoimmune conditions such as rheumatoid arthritis and lupus erythematosus. It functions by accumulating in lysosomes, raising intracellular pH to disrupt antigen processing and reduce inflammatory cytokine release. It has also been investigated as an antimalarial agent, interfering with heme polymerization in Plasmodium parasites.
Hydroxychloroquine is supplied as a solid, typically as the sulfate salt, conforming to pharmacopoeial standards including Ph.Eur. and USP specifications. Procurement should account for REACH compliance requirements applicable within the EU. Suppliers generally offer material in controlled pharmaceutical-grade packaging suited to GMP manufacturing environments.
In pharmaceutical manufacturing, hydroxychloroquine serves as an active pharmaceutical ingredient in formulations targeting autoimmune conditions such as rheumatoid arthritis and lupus erythematosus. It functions by accumulating in lysosomes, raising intracellular pH to disrupt antigen processing and reduce inflammatory cytokine release. It has also been investigated as an antimalarial agent, interfering with heme polymerization in Plasmodium parasites.
Hydroxychloroquine is supplied as a solid, typically as the sulfate salt, conforming to pharmacopoeial standards including Ph.Eur. and USP specifications. Procurement should account for REACH compliance requirements applicable within the EU. Suppliers generally offer material in controlled pharmaceutical-grade packaging suited to GMP manufacturing environments.
Physical Properties
| Melting Point | 90 °C |
| Boiling Point | 516.7±50.0 °C(Predicted) |
| Density | 1.1438 (rough estimate) |
| Color | White to Off-White |
| Form | Solid |
| Refractive Index | 1.5790 (estimate) |
Trade & Regulatory
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 1 |
Other Names
C07043win1258WIN 1258plaquenilWin 1258-2OxychlorochinOxychloroquine2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol
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