Hydroxyproline
CAS 51-35-4
EC 200-091-9
Formula C5H9NO3
MW 131.13 g/mol
Amino Acids & Peptides Personal Care & CosmeticsPharmaceuticals & HealthcareFood & Nutrition Humectant & MoisturizingAntioxidant & StabilizerpH Regulation & Buffering
Description
Hydroxyproline (CAS 51-35-4) is a non-essential amino acid derived primarily from collagen hydrolysis, commercially identified under abbreviations including H-HYP-OH, c4-OH-Pro, and Hypro. It carries no assigned E-code and is classified under HS code 29339990 for customs purposes.
In personal care formulations, hydroxyproline functions as a skin and hair conditioner by binding water molecules within the stratum corneum, improving moisture retention without occlusion. In pharmaceutical and food applications, it serves as a buffering agent and heat stabilizer, maintaining structural integrity of peptide-based preparations under thermal stress.
Hydroxyproline is available in pharmaceutical-grade (Ph.Eur. compliant) and food-grade (FCC compliant) crystalline powder forms, with REACH registration applicable for EU market supply. Procurement quantities typically range from kilogram packs to multi-tonne bulk, with certificates of analysis and full regulatory documentation available upon request.
In personal care formulations, hydroxyproline functions as a skin and hair conditioner by binding water molecules within the stratum corneum, improving moisture retention without occlusion. In pharmaceutical and food applications, it serves as a buffering agent and heat stabilizer, maintaining structural integrity of peptide-based preparations under thermal stress.
Hydroxyproline is available in pharmaceutical-grade (Ph.Eur. compliant) and food-grade (FCC compliant) crystalline powder forms, with REACH registration applicable for EU market supply. Procurement quantities typically range from kilogram packs to multi-tonne bulk, with certificates of analysis and full regulatory documentation available upon request.
Physical Properties
| Melting Point | 274 °C |
| Boiling Point | 242.42°C (rough estimate) |
| Density | 1.478 g/cm³ |
| Appearance | White crystalline powder |
| Color | White |
| Odor | Odorless |
| Form | Crystals or Crystalline Powder |
| Water Solubility | 357.8 g/L (20 º C) |
| Refractive Index | -75.5 ° (C=4, H2O) |
| pH | 5.5-6.5 (50g/l, H2O, 20℃) |
| Log P | -0.350 (est) |
Safety & Handling (Learn More)
Warning GHS07
H
H315H319H335
P
P261P264P271P280P319P321P405P501P264+P265P302+P352P304+P340P332+P317P337+P317P362+P364P403+P233P305+P351+P338
Trade & Regulatory
| HS Code | 29339990 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
trans-4-Hydroxy-L-proline(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acidHypc4-OH-ProHyproH-HYP-OH4-HydroxyprolineH-HYP-OH (TRANS)L-Hydroxyproline
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