Isethionic acid
CAS 107-36-8
EC 203-484-3
Formula C2H6O4S
MW 126.13 g/mol
Organic Acids Personal Care & CosmeticsPharmaceuticals & HealthcareTextile, Leather & Paper Emulsification & DispersionpH Regulation & BufferingSolvent & Carrier
Description
Isethionic acid (CAS 107-36-8, EC 203-484-3) is a sulfonated organic acid also known as ethanolsulfonic acid or hydroxyethylsulfonic acid. It carries no assigned E-code and is commercially handled as an aqueous solution under these common trade names across European markets.
In personal care formulations, isethionic acid serves as the acidic precursor in the synthesis of sodium cocoyl isethionate, where its sulfonate group reacts with fatty acid chlorides to produce mild surfactants. In pharmaceutical manufacturing, it functions as a pH-regulating agent and counterion in salt formation, improving the solubility profile of active compounds.
Isethionic acid is supplied as an aqueous solution and falls under REACH registration requirements for European procurement. Buyers should confirm grade specifications against relevant pharmacopoeial or industrial standards prior to use. Standard packaging formats for bulk industrial supply typically include IBC containers and drums.
In personal care formulations, isethionic acid serves as the acidic precursor in the synthesis of sodium cocoyl isethionate, where its sulfonate group reacts with fatty acid chlorides to produce mild surfactants. In pharmaceutical manufacturing, it functions as a pH-regulating agent and counterion in salt formation, improving the solubility profile of active compounds.
Isethionic acid is supplied as an aqueous solution and falls under REACH registration requirements for European procurement. Buyers should confirm grade specifications against relevant pharmacopoeial or industrial standards prior to use. Standard packaging formats for bulk industrial supply typically include IBC containers and drums.
Physical Properties
| Melting Point | <25 °C |
| Boiling Point | 226°C at 101.3kPa |
| Density | 1.344 (estimate) |
| Appearance | Liquid. Very soluble in water; insoluble in alcohol. |
| Color | Colorless to light yellow |
| Form | Colourless Solution |
| Vapor Pressure | 0Pa at 25℃ |
| Refractive Index | 1.5090 (estimate) |
| Log P | -1.65 at 25℃ and pH2 |
Safety & Handling (Learn More)
Danger GHS05
H
H314H318H412
P
P260P264P273P280P316P317P321P363P405P501P264+P265P304+P340P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 2930909899 |
Other Names
2-hydroxyethanesulfonic acidEthanolsulfonateSodium isethionateKyselina isethionovaisethionicTego HES 70isothionicacid
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