Isobutyl chloroformate

Isobutyl chloroformate (CAS 543-27-1), also known as isobutyl chlorocarbonate or isobutoxycarbonyl chloride, is a reactive acylating agent belonging to the chloroformate ester family. It carries no assigned E-code and is classified under HS code 29159000. It is supplied as a colorless to light-colored liquid.

In pharmaceutical synthesis, isobutyl chloroformate activates carboxylic acids to form mixed anhydrides, enabling efficient peptide coupling and prodrug esterification under mild conditions. In fragrance and flavor manufacturing, it serves as an intermediate for synthesizing ester-based aroma compounds. It also functions as a catalyst precursor in select organic reactions requiring controlled acylation.

This product is available in reagent and technical grades and is subject to REACH registration requirements for supply within the EU. Procurement quantities typically range from laboratory scale to bulk industrial volumes. Buyers should verify current SDS documentation and confirm grade specifications prior to formulation or synthesis use.