Itraconazole

Itraconazole (CAS 84625-61-6) is a synthetic triazole antifungal compound, also known by the abbreviations ITCZ and R-51211, and marketed under trade names including Sempera and Orungal. It carries no assigned E-code. Its molecular formula is C35H38Cl2N8O4.

In pharmaceutical manufacturing, itraconazole serves as an active pharmaceutical ingredient targeting fungal cell membrane synthesis by inhibiting lanosterol 14-alpha-demethylase, disrupting ergosterol production. Research formulations also explore its activity in flame-retardant systems, where its halogen and nitrogen content contribute to char formation and combustion interruption at the polymer interface.

Itraconazole is supplied as an off-white crystalline powder meeting Ph.Eur. monograph specifications, with REACH compliance documentation available for EU procurement. Manufacturers should confirm purity grade requirements prior to ordering, as pharmaceutical-grade material carries distinct quality release criteria. Standard packaging formats include sealed drums and multi-layer bags suited for controlled-environment storage.