(-)-Menthol

(-)-Menthol (CAS 2216-51-5, EC 218-690-9, FEMA 2665) is the naturally occurring enantiomer of menthol, also referred to as l-Menthol or 1-menthol. It is the optically active form responsible for the characteristic cooling sensation associated with peppermint, and is the predominant form used across food, cosmetic, and pharmaceutical manufacturing.

In oral care and confectionery, (-)-Menthol activates TRPM8 cold receptors on the tongue and mucous membranes, producing a cooling effect without a temperature change. In topical pharmaceutical formulations, it functions as a penetration enhancer and counterirritant, while in fragrance compounding it contributes a sharp, minty top note at concentrations typically below 1%.

(-)-Menthol is available in natural and synthetic grades, supplied as crystals or crystalline needles, and meets specifications under Ph.Eur., FCC, and REACH registration requirements. It is classified under HS code 29061100. Procurement teams should confirm grade suitability against the intended application prior to ordering.