Methyl gentisate

Methyl gentisate (CAS 2150-46-1, EC 218-427-8) is the methyl ester of gentisic acid, also referred to as methyl 2,5-dihydroxybenzoate or methoxycarbonylhydroquinone. It belongs to the hydroxybenzoate family and carries no assigned E-code, distinguishing it from common food-grade parabens.

In pharmaceutical synthesis, methyl gentisate serves as a key intermediate in the preparation of active compounds where the 2,5-dihydroxyphenyl scaffold is required. Its dual phenolic hydroxyl groups provide measurable antioxidant activity by scavenging free radicals, making it relevant in cosmetic formulations designed to protect against oxidative degradation of sensitive ingredients.

Methyl gentisate is supplied as a pharmaceutical-grade material aligned with REACH registration requirements for the European market. Procurement teams should confirm purity specifications and batch documentation with the supplier, as grade suitability varies across pharmaceutical, personal care, and food-related applications.