Metronidazole
CAS 443-48-1
EC 207-136-1
Formula C6H9N3O3
MW 171.15 g/mol
Heterocyclic Compounds Pharmaceuticals & HealthcarePersonal Care & Cosmetics Preservation & BiocidepH Regulation & BufferingHumectant & Moisturizing
Description
Metronidazole (CAS 443-48-1) is a synthetic nitroimidazole compound used as an active pharmaceutical ingredient and functional additive. It is commercially known under trade names including Nida, Klion, Klont, Cont, and Eumin. No E-code designation applies to this substance.
In pharmaceutical formulations, metronidazole acts as an antimicrobial agent by disrupting DNA synthesis in anaerobic bacteria and protozoa, making it a primary active in topical gels and oral dosage forms targeting infections. In cosmetic applications, it functions as a skin conditioner and humectant, supporting moisture retention in dermatological creams targeting rosacea and inflammatory skin conditions.
Metronidazole is available in pharmaceutical-grade crystalline powder compliant with Ph.Eur. and USP monographs. It is subject to REACH registration requirements for EU supply. Standard packaging formats include fiber drums and double polyethylene-lined bags, with documentation available to support GMP procurement workflows.
In pharmaceutical formulations, metronidazole acts as an antimicrobial agent by disrupting DNA synthesis in anaerobic bacteria and protozoa, making it a primary active in topical gels and oral dosage forms targeting infections. In cosmetic applications, it functions as a skin conditioner and humectant, supporting moisture retention in dermatological creams targeting rosacea and inflammatory skin conditions.
Metronidazole is available in pharmaceutical-grade crystalline powder compliant with Ph.Eur. and USP monographs. It is subject to REACH registration requirements for EU supply. Standard packaging formats include fiber drums and double polyethylene-lined bags, with documentation available to support GMP procurement workflows.
Physical Properties
| Melting Point | 158-160 °C |
| Boiling Point | 301.12°C (rough estimate) |
| Density | 1.45 g/cm³ |
| Flash Point | 9°C |
| Appearance | Metronidazole is an odorless, white, yellow, or cream-colored crystalline solid. Darkens on exposure to light. Bitter, salty taste (do not test). |
| Color | white to light yellow |
| Form | crystalline |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Refractive Index | 1.5800 (estimate) |
| Log P | -0.02 |
Safety & Handling (Learn More)
Danger GHS07 GHS08
H
H302H312H332H341H350H351H373H412
P
P203P260P261P264P270P271P273P280P317P318P319P321P330P405P501P301+P317P302+P352P304+P340P362+P364
Trade & Regulatory
| HS Code | 29332990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| WGK (Germany) | 3 |
Other Names
2-(2-methyl-5-nitroimidazol-1-yl)ethanol2-methyl-5-nitroimidazole-1-ethanol1-(β-oxyethyl)-2-methyl-5-nitroimidazole1-(β-ethylol)-2-methyl-5-nitro-3-azapyrroleContNidaKlontEuminBexon
Related Products
Raw Materials
Need a chemical? Get a quote within 24 hours.