N-Hydroxysuccinimide
CAS 6066-82-6
EC 228-001-3
Formula C4H5NO3
MW 115.09 g/mol
Heterocyclic Compounds Personal Care & CosmeticsPharmaceuticals & Healthcare Humectant & MoisturizingPreservation & BiocideUV Protection & Stabilization
Description
N-Hydroxysuccinimide (CAS 6066-82-6), also known as HOSU, HONSU, or NSC 74335, is a cyclic imide compound classified under heterocyclic chemistry. It carries no assigned E-code. It is supplied under EC number 228-001-3 and registered under REACH for commercial use within the European Economic Area.
In pharmaceutical formulations, N-Hydroxysuccinimide functions as a reactive coupling agent, activating carboxylic acid groups to form NHS esters that bind proteins and biomolecules with high selectivity. In personal care applications, it acts as a humectant by retaining moisture at the skin surface and contributes UV-stabilising activity that helps protect formulations from photodegradation.
This material is available in solid and liquid grades suitable for pharmaceutical and cosmetic manufacturing. Relevant compliance frameworks include REACH registration and pharmaceutical-grade specifications aligned with Ph.Eur. standards. Procurement enquiries for bulk and laboratory-scale packaging are handled through our European distribution network.
In pharmaceutical formulations, N-Hydroxysuccinimide functions as a reactive coupling agent, activating carboxylic acid groups to form NHS esters that bind proteins and biomolecules with high selectivity. In personal care applications, it acts as a humectant by retaining moisture at the skin surface and contributes UV-stabilising activity that helps protect formulations from photodegradation.
This material is available in solid and liquid grades suitable for pharmaceutical and cosmetic manufacturing. Relevant compliance frameworks include REACH registration and pharmaceutical-grade specifications aligned with Ph.Eur. standards. Procurement enquiries for bulk and laboratory-scale packaging are handled through our European distribution network.
Physical Properties
| Melting Point | 97-98 °C |
| Boiling Point | 215.33°C (rough estimate) |
| Density | 1.4769 (rough estimate) |
| Appearance | White to pale yellow |
| Color | Clear yellow-brown to brown |
| Form | Liquid or Solid |
| Water Solubility | SOLUBLE |
| Vapor Pressure | 0Pa at 25℃ |
| Refractive Index | 1.4080 (estimate) |
| pH | 5-7 (50g/l, H2O, 20℃) |
| Log P | -2.01 |
Safety & Handling (Learn More)
Warning GHS07
H
H315H319H335
P
P261P264P271P280P319P321P405P501P264+P265P302+P352P304+P340P332+P317P337+P317P362+P364P403+P233P305+P351+P338
Trade & Regulatory
| HS Code | 29251995 |
| WGK (Germany) | 3 |
Other Names
1-hydroxypyrrolidine-2,5-dioneN -Hydroxysuccinimide，NHSNHSHOSUHONSUHydroxysuccinimideN-HYDROXYSUCCINIMDE1-HydroxysuccinimideSuccinimide, N-hydroxy-
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Raw Materials
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