n-Methylmorpholine
CAS 109-02-4
EC 203-640-0
Formula C5H11NO
MW 101.15 g/mol
Amines Plastics & PolymersPharmaceuticals & HealthcarePrinting & Packaging CatalysisPreservation & Biocide
Description
N-Methylmorpholine (NMM) is a tertiary amine supplied as a clear liquid under trade names including Jeffcat NMM, KL 21, and NSC 9382. It carries CAS number 109-02-4 and EC number 203-640-0. No E-code applies to this substance.
In pharmaceutical synthesis, NMM acts as a non-nucleophilic base and catalyst in peptide coupling reactions, activating carbodiimide reagents without interfering with the peptide bond. In polyurethane production, it accelerates the reaction between isocyanates and polyols, controlling foam cell structure and cure rate. It also functions as a biocide and preservative in printing formulations.
NMM is available in technical and pharmaceutical-grade formats, with supply subject to REACH registration requirements for EU procurement. Packaging typically includes drums and IBC containers. Buyers should confirm grade specification against Ph.Eur. or internal quality standards depending on end-use application. HS code 29349990 applies for import classification.
In pharmaceutical synthesis, NMM acts as a non-nucleophilic base and catalyst in peptide coupling reactions, activating carbodiimide reagents without interfering with the peptide bond. In polyurethane production, it accelerates the reaction between isocyanates and polyols, controlling foam cell structure and cure rate. It also functions as a biocide and preservative in printing formulations.
NMM is available in technical and pharmaceutical-grade formats, with supply subject to REACH registration requirements for EU procurement. Packaging typically includes drums and IBC containers. Buyers should confirm grade specification against Ph.Eur. or internal quality standards depending on end-use application. HS code 29349990 applies for import classification.
Physical Properties
| Melting Point | −66 °C(lit.) |
| Boiling Point | 115 °C |
| Density | 0.91406 g/cm³ @ Temp: 25.00 °C |
| Flash Point | 75 °F |
| Appearance | clear liquid |
| Color | Clear |
| Form | Liquid |
| Water Solubility | >500 g/L (20 ºC) |
| Vapor Pressure | 18 mm Hg ( 20 °C) |
| Refractive Index | n 20/D 1.435(lit.) |
| pH | 10.6 (50g/l, H2O, 20℃) |
| Log P | -0.32 at 25℃ |
Safety & Handling (Learn More)
Danger GHS02 GHS05 GHS07
H
H225H302H312H314H318H332
P
P210P233P240P241P242P243P260P261P264P270P271P280P316P317P321P330P363P405P501P264+P265P301+P317P302+P352P304+P340P362+P364P370+P378P403+P235P301+P330+P331P302+P361+P354P303+P361+P353P305+P354+P338
Trade & Regulatory
| HS Code | 29349990 |
| UN Number | 2535 |
| ADR Class | 3 |
| Packing Group | II |
| WGK (Germany) | 1 |
Other Names
4-MethylmorpholineNMMKL 21Jeffcat NMM4-MethylmorfolinLUPRAGEN(R) N 105
Related Products
Raw Materials
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