N-Stearoyl phytosphingosine

N-Stearoyl Phytosphingosine, commonly known as Ceramide 3 or Ceramide III and marketed under names including DS-CeraMide Y3S and C18-Phytoceramide, is a synthetic ceramide consisting of a phytosphingosine backbone linked to stearic acid. It carries no assigned E-code. CAS 34354-88-6.

In skin barrier formulations, it integrates into the lipid matrix of the stratum corneum, reducing transepidermal water loss by reinforcing intercellular lamellar structures. Formulators incorporate it into emulsions and topical pharmaceutical preparations where it acts as both a humectant and a structural lipid, improving moisture retention and emulsion stability at low concentrations.

N-Stearoyl Phytosphingosine is supplied as a solid and is subject to REACH registration requirements for EU market access. Manufacturers should verify supplier compliance documentation and confirm suitability for cosmetic or pharmaceutical use under applicable regional regulations. Packaging formats vary by supplier and order volume.