Pantoprazole sodium sesquihydrate

Pantoprazole sodium sesquihydrate (CAS 164579-32-2) is a sodium salt form of the proton pump inhibitor pantoprazole, commonly referenced under trade names such as Allpan, PANTOP, Pantosec, and Pantodac, and abbreviated as PAN. It carries no assigned E-code and is classified as a pharmaceutical intermediate.

The compound is used primarily in the manufacture of finished-dose gastric acid suppression medications, where it irreversibly binds to the hydrogen-potassium ATPase enzyme in gastric parietal cells, blocking acid secretion. It is also employed in the production of enteric-coated tablets and intravenous formulations targeting gastroesophageal reflux disease and peptic ulcer conditions.

Pantoprazole sodium sesquihydrate is supplied to pharmaceutical manufacturers in grades conforming to Ph.Eur. and USP monograph specifications. It falls under HS code 2933399090 and is subject to REACH registration requirements within the European Union. Packaging is typically provided in sealed drums or double-lined bags suited to GMP-compliant handling environments.