Pioglitazone

Pioglitazone (CAS 105355-27-9, formula C19H20N2O3S) is a thiazolidinedione compound known under the trade names Zactos and U 72107. It is a selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor that regulates glucose and lipid metabolism.

Pioglitazone serves primarily as an active pharmaceutical ingredient in the synthesis of antidiabetic drug formulations targeting type 2 diabetes mellitus. By activating PPARγ, it enhances insulin sensitivity in adipose tissue, skeletal muscle, and the liver, reducing hepatic glucose output. It also functions as a reference standard and research tool in metabolic disease studies.

Pioglitazone is supplied as a pharmaceutical-grade solid, manufactured in compliance with ICH Q7 GMP guidelines and suitable for Ph.Eur. reference standards applications. It falls under REACH registration requirements for European procurement. Packaging is available in research quantities through to bulk formats depending on supplier specification.