Pioglitazone
CAS 111025-46-8
EC 601-029-7
Formula C19H20N2O3S
MW 356.44 g/mol
Pharmaceutical Intermediates Pharmaceuticals & HealthcarePersonal Care & Cosmetics Antioxidant & StabilizerUV Protection & StabilizationPreservation & Biocide
Description
Pioglitazone (CAS 111025-46-8, EC 601-029-7, formula C19H20N2O3S) is a thiazolidinedione compound commercially known under the trade names Actos and Zactos, and referenced in research as U 72107 or (RS)-pioglitazone. It carries no assigned E-code and is classified as a pharmaceutical intermediate.
In pharmaceutical formulation, pioglitazone functions as an active ingredient targeting insulin resistance pathways, making it relevant to antidiabetic drug manufacturing. In personal care applications, it is evaluated for skin-conditioning and protective effects, where its antioxidant and stabilizing properties help mitigate oxidative stress at the formulation level. Its UV-absorbing characteristics also support stabilization roles in specific topical systems.
Pioglitazone is supplied as a white to off-white solid meeting pharmaceutical-grade specifications aligned with Ph.Eur. and ICH quality standards. It falls under REACH registration requirements for European supply. Procurement teams should confirm grade, purity documentation, and packaging format directly with the supplier.
In pharmaceutical formulation, pioglitazone functions as an active ingredient targeting insulin resistance pathways, making it relevant to antidiabetic drug manufacturing. In personal care applications, it is evaluated for skin-conditioning and protective effects, where its antioxidant and stabilizing properties help mitigate oxidative stress at the formulation level. Its UV-absorbing characteristics also support stabilization roles in specific topical systems.
Pioglitazone is supplied as a white to off-white solid meeting pharmaceutical-grade specifications aligned with Ph.Eur. and ICH quality standards. It falls under REACH registration requirements for European supply. Procurement teams should confirm grade, purity documentation, and packaging format directly with the supplier.
Physical Properties
| Melting Point | 183-184 °C |
| Boiling Point | 575.4±45.0 °C(Predicted) |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Color | White to Off-White |
| Form | White to off-white solid. |
Safety & Handling (Learn More)
Warning GHS07 GHS08
H
H302H312H315H319H332H335H351H302+H312+H332
P
P203P261P264P270P271P280P317P318P319P321P330P405P501P264+P265P301+P317P302+P352P304+P340P332+P317P337+P317P362+P364P403+P233P305+P351+P338
Other Names
(RS)-pioglitazoneActosZactosU 72107PINEPOLLENPioglitazone (Actos)Pioglitazone free basePioglitazone and its intermeidates
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