Pivaloyl chloride

Pivaloyl chloride (CAS 3282-30-2, EC 221-921-6, formula C5H9ClO) is an acyl chloride also known as pivalyl chloride, pivalic acid chloride, and neopentanoyl chloride. It carries no assigned E-code and is classified as a pharmaceutical intermediate under HS code 29159080.

In pharmaceutical synthesis, pivaloyl chloride acts as an acylating agent to form mixed anhydrides, enabling selective activation of carboxylic acids during antibiotic and peptide manufacturing. In agrochemical production, it serves as a reactive intermediate for synthesizing herbicide and fungicide active substances, where its steric bulk controls regioselectivity during coupling reactions.

Pivaloyl chloride is supplied as a liquid-phase reagent in technical and high-purity grades suitable for pharmaceutical and agrochemical manufacturing under REACH compliance. Procurement teams should confirm supplier documentation covering SDS, CoA, and REACH registration status prior to import into EU member states.