S-Adenosyl methionine

S-Adenosyl Methionine (CAS 29908-03-0), commonly abbreviated as SAM or SAM-e and also known by the INN Ademetionine, is a naturally occurring sulfonium compound biosynthesised from methionine and ATP. It carries no assigned E-code and is distinct from simple amino acid derivatives in its biological activity.

In pharmaceutical formulations, SAM-e functions as a methyl-group donor in transmethylation reactions, supporting hepatoprotective and antidepressant drug development. In personal care applications, it acts as a skin conditioner and antioxidant by scavenging reactive oxygen species and supporting cellular repair pathways, making it relevant to anti-ageing and barrier-protection formulations.

This material is supplied as a solid, typically as the tosylate or disulfate salt to improve stability, and is available in pharmaceutical-grade specifications aligned with Ph.Eur. monograph requirements. It falls under HS code 29349990 and is subject to REACH registration obligations for EU import and use.