Sertraline hydrochloride

Sertraline hydrochloride (CAS 79559-97-0) is a selective serotonin reuptake inhibitor supplied as a pharmaceutical active ingredient. It is commercially recognised under the trade names Zoloft, Lustral, Atruline, Lesefer, and Sosser. No E-code designation applies to this substance.

In pharmaceutical manufacturing, sertraline hydrochloride serves as the active pharmaceutical ingredient in solid oral dosage forms, primarily film-coated tablets and capsules indicated for depressive and anxiety disorders. It functions by blocking the serotonin transporter protein, increasing synaptic serotonin availability. It is also used as a reference standard and synthetic intermediate in API process development and analytical method validation.

Sertraline hydrochloride is available in pharmaceutical-grade form compliant with Ph.Eur. monograph specifications and applicable ICH guidelines. The substance falls under REACH regulation and requires handling in accordance with EU GMP standards for active substances. Packaging is typically supplied in sealed, moisture-controlled containers suited to API handling requirements.