Tbdmscl
CAS 18162-48-6
EC 242-042-4
Formula C6H15ClSi
MW 150.72 g/mol
Organometallic Compounds Biotechnology & Life SciencesPharmaceuticals & HealthcarePlastics & PolymersElectronics Cross-linking & CuringSurface Modification & WettingSolvent & Carrier
Description
TBDMS chloride (CAS 18162-48-6, EC 242-042-4) is an organosilicon reagent used to introduce tert-butyldimethylsilyl protecting groups onto hydroxyl and other nucleophilic functional groups. Also known as TBDMSCL, TBSCL, TBDMCS, and TBDMSCl, it carries no assigned E-code and is classified under HS code 29310095.
In pharmaceutical synthesis, TBDMS chloride selectively protects alcohol and amine groups during multi-step reactions, allowing subsequent transformations to proceed without unwanted side reactions. In electronics and polymer applications, it functions as a surface modifier and crosslinker by reacting with silanol groups on substrates, improving adhesion and controlling wetting behaviour at interfaces.
TBDMS chloride is supplied as a technical-grade solid or liquid and is subject to REACH registration requirements within the European Economic Area. Procurement teams should confirm purity specifications and SDS documentation prior to ordering, as grade requirements vary between pharmaceutical and industrial polymer applications.
In pharmaceutical synthesis, TBDMS chloride selectively protects alcohol and amine groups during multi-step reactions, allowing subsequent transformations to proceed without unwanted side reactions. In electronics and polymer applications, it functions as a surface modifier and crosslinker by reacting with silanol groups on substrates, improving adhesion and controlling wetting behaviour at interfaces.
TBDMS chloride is supplied as a technical-grade solid or liquid and is subject to REACH registration requirements within the European Economic Area. Procurement teams should confirm purity specifications and SDS documentation prior to ordering, as grade requirements vary between pharmaceutical and industrial polymer applications.
Physical Properties
| Melting Point | 112-114 °C |
| Boiling Point | 126.00 °C |
| Density | 0.872 g/cm³ |
| Flash Point | 73 °F |
| Appearance | White solid |
| Color | Clear colorless |
| Form | Liquid |
| Water Solubility | Soluble in chloroform and ethyl acetate. Insoluble in water. |
| Vapor Pressure | 60-710Pa at 25℃ |
| Refractive Index | n 20/D 1.46 |
| Log P | 2.5 at 20℃ |
Safety & Handling (Learn More)
Danger GHS02 GHS05 GHS07 GHS09
H
H228H314H318H335H411
P
P210P240P241P260P261P264P271P273P280P316P317P319P321P363P391P405P501P264+P265P304+P340P370+P378P403+P233P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 29310095 |
| UN Number | 2925 |
| ADR Class | 4.1 |
| Packing Group | II |
| Storage Class | 4.1B - Flammable solid hazardous materials |
| WGK (Germany) | 2 |
Other Names
Tert-Butyldimethylsilyl Chloridetert-butyl-chloro-dimethylsilaneTBDMS chloridet-butyldimethylchlorosilanetert-butyldimethylchlorosilaneBDCSTBSCLTBDMCl
Related Products
Raw Materials
Derivatives
Need a chemical? Get a quote within 24 hours.