Tetrahydrofuran

Tetrahydrofuran (THF), also known as oxacyclopentane or butane 1,4-epoxide, is a cyclic ether solvent with CAS number 109-99-9. It carries no assigned E-code and is commercially identified under synonyms including furanidine and butane α,δ-oxide. It is classified under HS code 29321100 for customs and trade purposes.

In pharmaceutical manufacturing, THF functions as a reaction solvent and carrier medium, dissolving a broad range of polar and nonpolar active compounds to facilitate synthesis and formulation steps. In personal care and home care applications, it serves as a solvent carrier that enables uniform dispersion of fragrance and functional ingredients within a product matrix.

THF is available in technical, reagent, and pharmaceutical grades, with pharmaceutical-grade material conforming to Ph.Eur. and USP specifications. It falls under REACH regulation and requires an SDS compliant with EU standards. Packaging is typically supplied in drums and IBCs suited to industrial procurement volumes.