Triethyl orthoformate

Triethyl orthoformate (CAS 122-51-0) is an orthoester compound commercially available under trade names including Aethon and Ethone. It carries no assigned E-code and is classified under HS code 29159080. The molecular formula is C7H16O3.

In pharmaceutical synthesis, triethyl orthoformate acts as a formylating and protecting agent, reacting selectively with amines and alcohols under mild acid catalysis to mask reactive functional groups during multi-step synthesis. In food and fragrance applications, it functions as a flavorant and aroma carrier, contributing fruity, ethereal notes at controlled concentrations. It also serves as an antimicrobial agent in certain preservation systems.

Triethyl orthoformate is supplied as a liquid in standard industrial drum and IBC formats, with grades available to meet FCC and pharmaceutical specifications. It falls under REACH registration requirements for supply within the EU. Buyers should confirm grade suitability against relevant pharmacopoeial or food-grade standards prior to procurement.