Triflic anhydride
CAS 358-23-6
EC 206-616-8
Formula C2F6O5S2
MW 282.14 g/mol
Monomers & Building Blocks Pharmaceuticals & HealthcarePlastics & Polymers Catalysis
Description
Triflic anhydride (CAS 358-23-6, EC 206-616-8) is the anhydride form of triflic acid, commonly abbreviated as Tf2O and also referred to as triflate anhydride. It carries no assigned E-code and is classified under HS code 29049020 within the monomers and building blocks category.
In pharmaceutical synthesis, Tf2O acts as a powerful electrophilic activating agent, converting hydroxyl groups into triflate leaving groups to enable nucleophilic substitution reactions that would otherwise be inaccessible. It also functions as a catalyst in polymer chemistry, initiating cationic polymerization, and serves as an intermediate in producing antimicrobial compounds and specialty colorants.
This product is supplied as a liquid under REACH registration and handled in accordance with applicable European chemical regulations. Procurement teams should confirm grade specifications and packaging formats directly with our technical team, as options vary depending on application requirements and order volume.
In pharmaceutical synthesis, Tf2O acts as a powerful electrophilic activating agent, converting hydroxyl groups into triflate leaving groups to enable nucleophilic substitution reactions that would otherwise be inaccessible. It also functions as a catalyst in polymer chemistry, initiating cationic polymerization, and serves as an intermediate in producing antimicrobial compounds and specialty colorants.
This product is supplied as a liquid under REACH registration and handled in accordance with applicable European chemical regulations. Procurement teams should confirm grade specifications and packaging formats directly with our technical team, as options vary depending on application requirements and order volume.
Physical Properties
| Melting Point | -80°C |
| Boiling Point | 84 °C |
| Density | 1.677 g/mL at 25 °C(lit.) |
| Flash Point | 81-83°C |
| Appearance | clear colorless to light brown liquid |
| Color | Clear colorless to light brown |
| Form | Liquid |
| Water Solubility | reacts violently with water |
| Vapor Pressure | 8 mm Hg ( 20 °C) |
| Refractive Index | n 20/D 1.321(lit.) |
| Log P | 0.3 at 25℃ |
Safety & Handling (Learn More)
Danger GHS03 GHS05 GHS07
H
H272H302H314H318H335
P
P210P220P260P261P264P270P271P280P316P317P319P321P330P363P405P501P264+P265P301+P317P304+P340P370+P378P403+P233P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 29049020 |
| UN Number | 3265 |
| ADR Class | 8 |
| Packing Group | II |
| Storage Class | 5.1B - Oxidizing hazardous materials |
| WGK (Germany) | 3 |
Other Names
Trifluoromethanesulfonic anhydridetrifluoromethylsulfonyl trifluoromethanesulfonate1,1,1-trifluoromethanesulfonic acid 1,1'-anhydrideTf2OPFC-MSATriflate anhydrideTrifluoromethylsulfonic anhydride
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