Trifluoroacetic acid
CAS 76-05-1
EC 200-929-3
Formula C2HF3O2
MW 114.02 g/mol
Organic Acids Textile, Leather & PaperPharmaceuticals & HealthcareFood & Nutrition Preservation & BiocidepH Regulation & BufferingFoam ControlFlame Retardancy
Description
Trifluoroacetic acid (TFA, CAS 76-05-1) is a strong perfluorinated organic acid also known as perfluoroacetic acid or trifluoroethanoic acid. It carries no assigned E-code and is classified under HS code 29159080. It is fully miscible with water and most organic solvents, making it compatible with a broad range of process chemistries.
In pharmaceutical manufacturing, TFA serves as an ion-pairing reagent in HPLC purification and as a deprotection agent in peptide synthesis, where its strong acidity cleaves acid-labile protecting groups efficiently. In textile and leather processing, it functions as a pH buffer and antimicrobial agent, controlling microbial growth during wet processing stages.
TFA is available in reagent, HPLC, and technical grades, with supply conforming to REACH registration requirements applicable in the EU market. Standard packaging includes glass bottles and HDPE containers across laboratory and bulk quantities. Procurement teams should verify grade specifications against Ph.Eur. or internal quality standards before ordering.
In pharmaceutical manufacturing, TFA serves as an ion-pairing reagent in HPLC purification and as a deprotection agent in peptide synthesis, where its strong acidity cleaves acid-labile protecting groups efficiently. In textile and leather processing, it functions as a pH buffer and antimicrobial agent, controlling microbial growth during wet processing stages.
TFA is available in reagent, HPLC, and technical grades, with supply conforming to REACH registration requirements applicable in the EU market. Standard packaging includes glass bottles and HDPE containers across laboratory and bulk quantities. Procurement teams should verify grade specifications against Ph.Eur. or internal quality standards before ordering.
Physical Properties
| Melting Point | -15.2 °C |
| Boiling Point | 72.4 °C |
| Density | 1.49 g/cm³ (liquid) @ Temp: 25 °C |
| Flash Point | None |
| Appearance | Colorless, fuming liquid; hygroscopic; pungent odor. Very soluble in water. Nonflammable. |
| Color | Colorless |
| Odor | Sharp, pungent odor |
| Form | Liquid |
| Water Solubility | miscible |
| Vapor Pressure | 97.5 mm Hg ( 20 °C) |
| Refractive Index | n 20/D 1.3(lit.) |
| pH | 1 (10g/l, H2O) |
Safety & Handling (Learn More)
Danger GHS05 GHS07 GHS06
H
H290H301H302H314H318H331H332H412
P
P234P260P261P264P270P271P273P280P316P317P321P330P363P390P405P406P501P264+P265P301+P316P301+P317P304+P340P403+P233P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 29159080 |
| UN Number | 2699 |
| ADR Class | 8 |
| Packing Group | I |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| WGK (Germany) | 2 |
Other Names
2,2,2-trifluoroacetic acidperfluoroacetic acidTFAIPC-PFFA-2MeSH ID: D014269RARECHEM AL BO 0421
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Raw Materials
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