Trifluoroacetic anhydride
CAS 407-25-0
EC 206-982-9
Formula C4F6O3
MW 210.03 g/mol
Organic Acids Plastics & PolymersPharmaceuticals & HealthcareTextile, Leather & PaperPrinting & Packaging Flame RetardancyFoam ControlPreservation & Biocide
Description
Trifluoroacetic anhydride (TFAA, CAS 407-25-0, EC 206-982-9) is an organic acid derivative formed from two trifluoroacetic acid units. It is also referenced under the names Trifluoroacetyl anhydride and NSC 96965. No E-code designation applies to this substance.
In pharmaceutical synthesis, TFAA acts as a powerful acylating agent, introducing trifluoroacetyl groups to amines and alcohols under mild conditions. In flame retardant formulations for plastics and polymers, it functions by releasing fluorine-containing species that interrupt combustion chain reactions. It also serves as an intermediate in antimicrobial and foam control additive production for textile and paper processing.
TFAA is supplied as a reagent-grade liquid and falls under REACH registration requirements for European procurement. Buyers should confirm supplier SDS documentation and confirm compliance with applicable industrial chemical regulations before use. Standard packaging formats include glass bottles and stainless steel containers suited to its reactive and moisture-sensitive nature.
In pharmaceutical synthesis, TFAA acts as a powerful acylating agent, introducing trifluoroacetyl groups to amines and alcohols under mild conditions. In flame retardant formulations for plastics and polymers, it functions by releasing fluorine-containing species that interrupt combustion chain reactions. It also serves as an intermediate in antimicrobial and foam control additive production for textile and paper processing.
TFAA is supplied as a reagent-grade liquid and falls under REACH registration requirements for European procurement. Buyers should confirm supplier SDS documentation and confirm compliance with applicable industrial chemical regulations before use. Standard packaging formats include glass bottles and stainless steel containers suited to its reactive and moisture-sensitive nature.
Physical Properties
| Melting Point | -65 °C |
| Boiling Point | 40 °C |
| Density | 1.511 g/cm³ (liquid) |
| Flash Point | -26 °C |
| Appearance | Clear, colorless liquid |
| Color | Clear |
| Form | Liquid |
| Water Solubility | Hydrolysis |
| Vapor Pressure | 6.28 psi ( 20 °C) |
| Refractive Index | n 20/D 1.3(lit.) |
| Log P | 0.79 at 25℃ |
Safety & Handling (Learn More)
Danger GHS05 GHS07 GHS08
H
H314H318H332H412
P
P203P260P261P264P271P273P280P316P317P318P321P363P405P501P264+P265P304+P340P301+P330+P331P302+P361+P354P305+P354+P338
Trade & Regulatory
| HS Code | 29159080 |
| UN Number | 3265 |
| ADR Class | 8 |
| Packing Group | I |
| Storage Class | 8B - Non-combustible corrosive hazardous materials |
| WGK (Germany) | 2 |
Other Names
(2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetateTFATFAATRIFLUORACETIC ANHYDRIDETrifluoroacetyl anhydridePerfluoroacetic anhydrideHexafluoroacetic anhydride
Related Products
Raw Materials
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