Trifluoromethanesulfonic acid
CAS 1493-13-6
EC 216-087-5
Formula CHF3O3S
MW 150.08 g/mol
Organic Acids Plastics & PolymersTextile, Leather & PaperPharmaceuticals & Healthcare pH Regulation & BufferingFlame RetardancyPreservation & BiocideCatalysis
Description
Trifluoromethanesulfonic acid (CAS 1493-13-6), also known as HOTf, TFMSA, FC-24, and PFC-MS, is a strong perfluorinated sulfonic acid with the formula CHF3O3S. It carries no assigned E-code. Its exceptional acidity and chemical stability distinguish it from conventional mineral acids in industrial applications.
In pharmaceutical synthesis, HOTf functions as a superacid catalyst, protonating substrates that resist activation by weaker acids and enabling reactions such as Friedel-Crafts alkylations under mild conditions. In textile and polymer processing, it contributes to flame retardancy by promoting char formation and disrupting combustion cycles, while its biocidal activity supports preservation in leather and paper treatments.
TFMSA is supplied under REACH compliance and is available in high-purity technical and synthesis grades as a fuming liquid, typically packaged in corrosion-resistant fluoropolymer or glass containers. Buyers should confirm grade specifications and SDS documentation prior to procurement. HS code 29049020 applies for import classification within the EU.
In pharmaceutical synthesis, HOTf functions as a superacid catalyst, protonating substrates that resist activation by weaker acids and enabling reactions such as Friedel-Crafts alkylations under mild conditions. In textile and polymer processing, it contributes to flame retardancy by promoting char formation and disrupting combustion cycles, while its biocidal activity supports preservation in leather and paper treatments.
TFMSA is supplied under REACH compliance and is available in high-purity technical and synthesis grades as a fuming liquid, typically packaged in corrosion-resistant fluoropolymer or glass containers. Buyers should confirm grade specifications and SDS documentation prior to procurement. HS code 29049020 applies for import classification within the EU.
Physical Properties
| Melting Point | <25 °C |
| Boiling Point | 162 °C |
| Density | 1.69 g/cm³ (liquid) |
| Flash Point | None |
| Appearance | Clear very light yellow liquid |
| Color | slightly brown |
| Form | Fuming Liquid |
| Water Solubility | SOLUBLE |
| Vapor Pressure | 8 mm Hg ( 25 °C) |
| Refractive Index | n 20/D 1.327(lit.) |
| pH | <1 (H2O) |
| Log P | 0.3 at 25℃ |
Safety & Handling (Learn More)
Warning GHS05 GHS07
H
H290H302H314H319H335
P
P234P260P261P264P270P271P280P316P319P321P330P363P390P405P406P501P264+P265P301+P317P304+P340P337+P317P403+P233P301+P330+P331P302+P361+P354P305+P351+P338P305+P354+P338
Trade & Regulatory
| HS Code | 29049020 |
| UN Number | 3265 |
| ADR Class | 8 |
| Packing Group | II |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| WGK (Germany) | 2 |
Other Names
TfOHCF3SO3Htriflic acidHOTfFC-24TFMSAPFC-MS
Related Products
Raw Materials
Derivatives
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