Trimethyl orthoacetate

Trimethyl orthoacetate (CAS 1445-45-0, EC 215-892-9), also known as methyl orthoacetate, trimethyl o-acetate, and 1,1,1-trimethoxyethane, is an orthoester derived from acetic acid with three methoxy groups. It carries no assigned E-code and is commercially handled as a liquid reagent under HS code 29159080.

In pharmaceutical synthesis, it functions as a mild acetylating agent and protecting-group reagent, reacting selectively with hydroxyl and amine functionalities under acidic conditions without generating strong acid byproducts. In food and flavour applications, it acts as a precursor releasing acetic acid esters that contribute characteristic fruity and vinegar-like notes, and it has documented antimicrobial activity relevant to preservation systems.

Trimethyl orthoacetate is available in technical and high-purity grades suitable for pharmaceutical and food-contact applications, with compliance assessed against REACH registration requirements. Packaging is typically supplied in drums or intermediate bulk containers, and buyers should confirm FCC or equivalent food-grade certification depending on end-use requirements.