Chapso

CHAPSO (CAS 82473-24-3), also known as 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate, is a zwitterionic detergent developed for membrane protein research and biochemical applications.

Where is Chapso used?

• Membrane protein research: solubilizes biological membranes while preserving native structure and activity of membrane-bound proteins
• Receptor binding studies and enzyme activity assays: standard reagent
• Pharmaceutical research: supports isolation of functionally intact membrane protein targets for drug discovery
• Two-dimensional crystallization: mild solubilization profile
• Lipid-protein reconstitution systems: maintains bilayer-like environments
• It is the detergent of choice for solubilizing and stabilizing integral membrane proteins during purification.

Good to know: Harsher detergents would cause irreversible denaturation in these sensitive environments. Lot-specific purity documentation is typically required for industrial use and GMP-adjacent pharmaceutical applications.

Commercial specifications

• Research-grade and high-purity biochemical grades
• Lot-specific purity documentation
• Pack sizes from small laboratory quantities up to bulk procurement for large-scale bioprocessing facilities