Ethylene oxide-propylene oxide block copolymer

Ethylene oxide-propylene oxide block copolymer (CAS 106392-12-5), commercially recognized as Poloxamer 388 and Nissan Plonon 207, is a nonionic block copolymer surfactant used across industrial and pharmaceutical manufacturing. Its amphiphilic structure enables controlled emulsification, foam regulation, and dispersion in aqueous systems where performance consistency is critical to formulation quality. In pharmaceutical manufacturing, it functions as a solubilizer.

It serves as a carrier for poorly water-soluble active ingredients, supporting both oral and topical drug delivery systems. Personal care formulators incorporate it into cleansing and conditioning products for stable emulsion formation. Pulp and paper operations use it as a defoamer and process aid to control foam buildup during pulping and coating stages. Textile and leather processing rely on it for wetting, scouring, and dispersing agents.

These applications improve dye penetration and substrate uniformity across various manufacturing environments. Ethylene oxide-propylene oxide block copolymer is typically supplied as a liquid or paste depending on the grade. Pharmaceutical-grade material is available to USP and Ph. Eur. specifications under the Poloxamer 388 monograph. This ensures the highest level of purity for sensitive medical and healthcare applications.

Technical-grade product is supplied for industrial applications in bulk and intermediate packaging formats. This versatile chemical remains a staple for formulators seeking reliable surfactant performance and stability.