Ethylene oxide-propylene oxide block copolymer

Ethylene oxide-propylene oxide block copolymer (CAS 106392-12-5), also marketed as Poloxamer 388 and Nissan Plonon 207, is a nonionic block copolymer surfactant used in industrial and pharmaceutical manufacturing.

Where is Ethylene oxide-propylene oxide block copolymer used?

• Pharmaceutical manufacturing: solubilizer and carrier for poorly water-soluble active ingredients in oral and topical drug delivery
• Personal care: stable emulsion formation in cleansing and conditioning products
• Pulp and paper: defoamer and process aid controlling foam during pulping and coating
• Textile and leather processing: wetting, scouring and dispersing agents that improve dye penetration and substrate uniformity
• Its amphiphilic structure enables controlled emulsification, foam regulation and dispersion in aqueous systems.

Good to know: Pharmaceutical-grade material meets USP and Ph. Eur. specifications under the Poloxamer 388 monograph.

Commercial specifications

• Technical grade in bulk and intermediate packaging