Triethylene glycol monochlorohydrin

Triethylene glycol monochlorohydrin (CAS 5197-62-6), also marketed as Provichem 0333, is a chlorinated glycol ether functioning as a reactive intermediate and solvent in specialty chemical synthesis. Its terminal chlorine group and free hydroxyl make it a practical building block for introducing polyether segments into target molecules. In pharmaceutical synthesis, it serves as an alkylating agent.

It is used for constructing PEGylated intermediates and ether-linked drug conjugates requiring precise chain length control. Agricultural chemical manufacturers use it to synthesize herbicide and pesticide intermediates. This occurs where a short ethylene oxide chain with a reactive chloride terminus is specified. In polymer chemistry, it acts as a chain-end functionalization agent and initiator for ring-opening polymerization.

This enables controlled incorporation of hydrophilic segments into polyurethane and polyether systems. Specialty surfactant producers also employ it as a precursor for nonionic and cationic amphiphile synthesis. Triethylene glycol monochlorohydrin is supplied as a liquid in bulk and drum quantities. Technical-grade material is the standard commercial offering, with purity specifications typically confirmed by GC assay.

Buyers sourcing for pharmaceutical or agrochemical intermediate applications should confirm lot-specific CoA documentation with suppliers to ensure the material meets the necessary performance requirements.