Triethylene glycol monochlorohydrin

Triethylene glycol monochlorohydrin (CAS 5197-62-6), also marketed as Provichem 0333, is a chlorinated glycol ether functioning as a reactive intermediate and solvent in specialty chemical synthesis.

Where is Triethylene glycol monochlorohydrin used?

• Pharmaceutical synthesis: alkylating agent
• Construction of PEGylated intermediates and ether-linked drug conjugates requiring precise chain length control
• Agricultural chemicals: synthesis of herbicide and pesticide intermediates
• Polymer chemistry: chain-end functionalization agent and initiator for ring-opening polymerization
• Specialty surfactants: precursor for nonionic and cationic amphiphile synthesis
• Its terminal chlorine group and free hydroxyl make it a practical building block for introducing polyether segments into target molecules.

Good to know: Buyers sourcing for pharmaceutical or agrochemical intermediate applications should confirm lot-specific CoA documentation with suppliers.

Commercial specifications

• Purity typically confirmed by GC assay
• Liquid in bulk and drum quantities