Glycylglycine

CAS Number
556-50-3
EC Number
209-127-8
Abbreviation
Gly-Gly

What is Glycylglycine?

Glycylglycine (CAS 556-50-3), also known as Gly-Gly and glycine dipeptide, is the simplest naturally occurring dipeptide, composed of two glycine residues.

Where is Glycylglycine used?

  • Pharmaceutical formulations: buffering agent maintaining stable pH in injectable solutions, protein therapeutics and lyophilized drug products
  • Cosmetics: humectant in moisturizing serums, creams and toners, attracting and retaining moisture at the skin surface
  • Biochemical research and peptide synthesis: reference standard and reagent
  • In cell culture media and enzyme assay systems it maintains physiological pH without interfering with biological activity.

Commercial specifications

  • High-purity lots supporting GMP-compliant manufacturing
  • Bulk quantities and smaller research-scale packaging

Other Names (Synonyms)

N-GLYCYL- Glycine|glycine dipeptide|Gly2|Gly-Gly|Diglycine (van)|alpha-Glycylglycine|2-(aminoacetamido)acetic acid|2-(2-aminoacetamido)acetic acid

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What are the physical properties of Glycylglycine?

Melting Point 215 °C (decomp)
Boiling Point 267.18°C (rough estimate)
Density 0.9938 g/cm³ @ Temp: 45.00 °C
Appearance White crystals
Color White
Form Solid
Water Solubility SOLUBLE IN HOT WATER
Vapor Pressure 0.058Pa at 20-50℃
Refractive Index 1.4880 (estimate)
pH 4.5-6.0 (20℃, 1M in H2O)
Log P -0.92 at 25℃ and pH6

How is Glycylglycine classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H319 Causes serious eye irritation

Precautionary Statements

P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264+P265 Wash … thoroughly after handling.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Which trade and regulatory codes apply to Glycylglycine?

HS Code 29241900
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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