Magnesium glycinate

Magnesium glycinate (CAS 14783-68-7), also known as magnesium diglycinate, is a chelated mineral salt combining magnesium with the amino acid glycine.

Where is Magnesium glycinate used?

• Dietary supplements: magnesium source for tablets, capsules and powdered drink mixes
• Pharmaceuticals: buffering and stabilizing agent in oral dosage forms sensitive to pH variation
• Food and functional nutrition: mineral fortification ingredient
• Cosmetics and personal care: moisturizing serums and skin conditioning products
• Its humectant properties support water retention in topical formulations.
• Used in oral solutions and syrups with a mild taste profile, suitable for evening intake.
• Used in moderately sweetened chewable gums and tablets with minimal metallic taste.
• Can be administered orally or intravenously.

Formulation notes

• Offers better gastrointestinal tolerability and bioavailability than other magnesium salts due to glycine chelation reducing free ion concentration in the intestine.
• An elemental magnesium specification well above the chelate ceiling suggests an oxide blend.

Typical specification

• Elemental magnesium specification of a magnesium glycinate grade should sit within roughly 10–14% for a chelate.
• A technical data sheet for magnesium glycinate should state specification ranges for elemental magnesium and free magnesium.
• Has high water solubility and a negative LogP, indicating favorable aqueous dissolution and low lipophilicity.

Regulatory status

• Heavy metal limits (Pb, Cd, As, Hg) must be met for food-grade and dietary supplement applications.
• Magnesium glycinate API manufacturers are required to follow Good Manufacturing Practices (GMP).

Storage, packaging and handling

• Should be stored at 4°C, sealed, away from moisture.
• Packaging options include bulk packaging for manufacturers and OEM or private-label packaging for brands.

Frequently asked questions about Magnesium glycinate

Which pharmacopoeia standard should buyers specify for magnesium glycinate API?

Buyers should specify the pharmacopoeia standard needed for magnesium glycinate API, such as EP (Ph. Eur.), USP, JP or BP.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.